Speaker
Description
In general, the 211At nuclide, a prospective candidate for targeted alpha radiotherapy, has been produced through the 208Bi(4He,2n)211At reaction. In contrast, our project is focused on the production in the 208Bi(7Li,2n)211At reaction using the JAEA tandem accelerator [1,2]. This enables us to supply 211At in a 211Rn/211At generator system. The daughter 211At of 7.2 h in half-life is generated through EC decay of the parent 211Rn of 14.7 h, expanding time-frame for transportation and use of 211At. In this project, chemical procedures based on dry- and wet-chemistry have been studied to develop the 211Rn/211At generator system. In addition, research subjects relating to the development of the 211Rn/211At generator system, namely, production of astatine and iodine radioisotopes [3, 4], astatine chemistry [5, 6, 7] as well as the analytical method of 211At using an alpha-scintillation camera and thin-layer chromatography [8] have been studied using the JAEA tandem accelerator. In the presentation, some experimental results in the project, e.g., production of astatine and iodine radioisotopes [2, 3, 4], the chemical procedure based on dry-chemistry for the 211Rn/211At generator system, and astatine chemistry [5, 6], will be presented.
[1] E. Maeda et al., J. Radioanal. Nucl. Chem. 303 (2015) 1465-1468.
[2] E. Maeda et al., J. Radioanal. Nucl. Chem. 323 (2020) 921-926.
[3] I. Nishinaka et al., J. Radioanal. Nucl. Chem. 304 (2015) 1077-1083.
[4] I. Nishinaka et al., J. Radioanal. Nucl. Chem. 314 (2017) 1947-1965.
[5] I. Nishinaka et al., J. Radioanal. Nucl. Chem. 318 (2018) 897-905.
[6] I. Nishinaka et al., J. Radioanal. Nucl. Chem. 322 (2019) 2003-2009.
[7] I. Nishinaka et al., J. Radioanal. Nucl. Chem. 327 (2021) 869-875.
[8] M. Segawa et al., J. Radioanal. Nucl. Chem. 326 (2020) 773-778.
